论文标题
通过多路复用图神经网络融合方式,以预测结核
Fusing Modalities by Multiplexed Graph Neural Networks for Outcome Prediction in Tuberculosis
论文作者
论文摘要
在诸如结核病等复杂疾病中,该疾病及其进化的证据可能存在于临床,基因组或成像数据等多种方式中。有效的患者制度预测和治疗指导将需要从这些方式中融合证据。这种多模式融合很困难,因为该疾病的证据在所有方式上可能并不均匀,并非所有模态特征都可能相关,或者并非所有患者都可能存在所有模式。所有这些细微差别使早期,晚期或中间融合的简单方法不足以预测结果。在本文中,我们提出了一个新型的融合框架,并使用多路复用图提出了一个新的图神经网络,以从此类图中学习。具体而言,该框架允许通过其目标编码来表示模式,并通过在组合的潜在空间中从显着特征得出的多路复用图明确建模其关系。我们提出的结果表明,我们所提出的方法的表现优于最先进的融合方法,用于在大结核病(TB)数据集上进行多种结果预测。
In a complex disease such as tuberculosis, the evidence for the disease and its evolution may be present in multiple modalities such as clinical, genomic, or imaging data. Effective patient-tailored outcome prediction and therapeutic guidance will require fusing evidence from these modalities. Such multimodal fusion is difficult since the evidence for the disease may not be uniform across all modalities, not all modality features may be relevant, or not all modalities may be present for all patients. All these nuances make simple methods of early, late, or intermediate fusion of features inadequate for outcome prediction. In this paper, we present a novel fusion framework using multiplexed graphs and derive a new graph neural network for learning from such graphs. Specifically, the framework allows modalities to be represented through their targeted encodings, and models their relationship explicitly via multiplexed graphs derived from salient features in a combined latent space. We present results that show that our proposed method outperforms state-of-the-art methods of fusing modalities for multi-outcome prediction on a large Tuberculosis (TB) dataset.