论文标题
由上细胞肌球蛋白束驱动的氢组织碎片的自发弯曲
Spontaneous Bending of Hydra Tissue Fragments Driven by Supracellular Actomyosin Bundles
论文作者
论文摘要
Hydra组织碎片在几分钟内从Hydra体弯曲自发弯曲到一些准稳定的形状。我们建议自发弯曲是由从亲本hydra继承的上细胞肌球蛋白束机械驱动的。构建了一个主动式固定板模型，从中我们可以预测以自发曲率为特征的片段由其收缩性和弹性的各向异性确定。通过存在软中间基质（Mesoglea）层来确保内胚侧向内弯曲。弯曲过程从边缘扩散地开始，并将指数放松至最终的准稳定形状。由于粘性阻力和层间摩擦滑动，从耗散中确定了两个特征时间尺度。前者约为0.01秒，但后者大得多，大约几分钟，与实验一致。
Hydra tissue fragments excised freshly from Hydra body bend spontaneously to some quasi-stable shape in several minutes. We propose that the spontaneous bending is driven mechanically by supracellular actomyosin bundles inherited from parent Hydra. An active-laminated-plate model is constructed, from which we predict that the fragment shape characterized by spontaneous curvature is determined by its anisotropy in contractility and elasticity. The inward bending to endoderm side is ensured by the presence of a soft intermediate matrix (mesoglea) layer. The bending process starts diffusively from the edges and relaxes exponentially to the final quasi-stable shape. Two characteristic time scales are identified from the dissipation due to viscous drag and interlayer frictional sliding, respectively. The former is about 0.01 seconds, but the latter is much larger, about several minutes, consistent with experiments.
