论文标题
从封闭式的第一笔计时时间推断
Inference from gated first-passage times
论文作者
论文摘要
首先时期为随机过程的基本特性提供了宝贵的见解。然而,各种形式的门控掩蔽时间第一邮器时间,并将它们与实际检测时间区分开。例如,不完美的条件可能会断断续续地观察感兴趣系统的能力,因此可能会遗漏精确的第一键实例。在其他情况下,例如某些化学反应,几乎不可能直接观察所涉及的分子,但是可以检测到反应事件本身。但是,由于某些分子遇到不育并且门控,此情况不必与第一次碰撞时间一致。在这种现实生活中所带来的挑战中,我们开发了一个通用的 - 无模型的框架,用于从封闭的第一阶段过程的检测时间推断第一邮器时间。此外,当已知基本运动定律时,我们的框架还提供了一种推断物理意义的参数的方法,例如扩散系数。最后,我们展示了如何通过迄今忽视的测量检测时间的短期策略来推断门控率本身。在几种身体相关性的环境中说明了我们方法的鲁棒性及其对基本细节的不敏感性。
First-passage times provide invaluable insight into fundamental properties of stochastic processes. Yet, various forms of gating mask first-passage times and differentiate them from actual detection times. For instance, imperfect conditions may intermittently gate our ability to observe a system of interest, such that exact first-passage instances might be missed. In other cases, e.g., certain chemical reactions, direct observation of the molecules involved is virtually impossible, but the reaction event itself can be detected. However, this instance need not coincide with the first collision time since some molecular encounters are infertile and hence gated. Motivated by the challenge posed by such real-life situations we develop a universal -- model-free -- framework for the inference of first-passage times from the detection times of gated first-passage processes. In addition, when the underlying laws of motions are known, our framework also provides a way to infer physically meaningful parameters, e.g. diffusion coefficients. Finally, we show how to infer the gating rates themselves via the hitherto overlooked short-time regime of the measured detection times. The robustness of our approach and its insensitivity to underlying details are illustrated in several settings of physical relevance.