论文标题
一种新的综合方法，用于在多个观察性研究中比较审查生存结果的多组比较
A New Integrative Method for Multigroup Comparisons of Censored Survival Outcomes in Multiple Observational Studies
论文作者
论文摘要
在观察性研究中，协变量失衡会产生混杂，从而导致比较。尽管基于倾向得分的加权方法有助于对隐式目标人群的不符组比较，但现有技术可能不会直接或有效地与多个组分析多个研究，并提供可推广到较大人群的结果。此外，很少有方法可以针对具有审查生存结果的各种估计值提供精确的推论。我们提出了一种新的一致目标人群方法，该方法构建了普遍的平衡权重和现实的目标人群。我们的方法可以通过适当补偿过度或代表性不足的群体以实现协变量平衡来纳入研究人员指定的自然人群属性并合成信息。对特定的估计量，估计和结果不可闻，构造的{coostant}权重不可知，并最大程度地提高了有效的样本量（ESS），以进行更精确的推论。在多个TCGA研究中，种族群体的胶质母细胞瘤结果的仿真研究和描述性比较证明了该策略的实际优势。与现有的加权技术不同，拟议的一致目标人群揭示了截然不同的结果：黑人更脆弱，预后较差。亚洲人的总体生存中位数为1,024天（SE：15.2）天，而白人和黑人的总生存期为1,024（SE：15.2）天。
In observational studies, covariate imbalance generates confounding, resulting in biased comparisons. Although propensity score-based weighting approaches facilitate unconfounded group comparisons for implicit target populations, existing techniques may not directly or efficiently analyze multiple studies with multiple groups and provide results generalizable to larger populations. Moreover, few methods deliver precise inferences for various estimands with censored survival outcomes. We propose a new concordant target population approach, which constructs generalized balancing weights and realistic target populations. Our method can incorporate researcher-specified natural population attributes and synthesize information by appropriately compensating for over- or under-represented groups to achieve covariate balance. The constructed {concordant} weights are agnostic to specific estimators, estimands, and outcomes and maximize the effective sample size (ESS) for more precise inferences. Simulation studies and descriptive comparisons of glioblastoma outcomes of racial groups in multiple TCGA studies demonstrate the strategy's practical advantages. Unlike existing weighting techniques, the proposed concordant target population revealed a drastically different result: Blacks were more vulnerable and endured significantly worse prognoses; Asians had the best outcomes with a median overall survival of 1,024 (SE: 15.2) days, compared to 384 (SE: 1.2) and 329 (SE: 19.7) days for Whites and Blacks, respectively.
