论文标题
异质性在指示上皮组织中肿瘤发生的作用
Role of heterogeneity in dictating tumorigenesis in epithelial tissues
论文作者
论文摘要
各个长度和时间尺度上的生物系统嘈杂，包括组织。为什么生物组织本质上是混乱的？异质性在确定组织的生理和病理学中起作用吗？物理和生化异质性串扰如何决定组织功能？在这篇综述中，我们从生物组织中的异质性进行简要介绍开始。然后，我们以最近的文献示例，表明生化和物理异质性的功能相关性，并讨论异质性对组织功能和病理学的影响。我们以对上皮组织的研究为例，讨论固有组织异质性在肿瘤发生中的潜在作用。
Biological systems across various length and time scales are noisy, including tissues. Why are biological tissues inherently chaotic? Does heterogeneity play a role in determining the physiology and pathology of tissues? How do physical and biochemical heterogeneity crosstalk to dictate tissue function? In this review, we begin with a brief primer on heterogeneity in biological tissues. Then, we take examples from recent literature indicating functional relevance of biochemical and physical heterogeneity and discuss the impact of heterogeneity on tissue function and pathology. We take specific examples from studies on epithelial tissues to discuss the potential role of inherent tissue heterogeneity in tumorigenesis.
