论文标题
人口规模对崎Fitness景观的早期适应的影响
Impact of population size on early adaptation in rugged fitness landscapes
论文作者
论文摘要
由于有限的种群大小（称为遗传漂移）引起的随机波动，探索坚固的健身景观的能力取决于其规模。在弱突变方案中，虽然平均稳态健身随着人口规模的增加而增加，但我们发现，从随机基因型开始时，第一个健身峰的高度也会显示出各种行为与人口大小，即使在小型和简单的坚固景观中。我们表明，不同适应性峰的可及性是确定该高度总体增加还是随人口规模降低的关键。此外，从随机基因型开始时，通常会有有限的种群大小可以最大化第一个健身峰的高度。在各种类别的崎landscapes中，峰以及某些实验性和实验性启发的模型景观中。因此，与大尺寸的限制相比，对于相对较小的人口规模，崎and的健身景观的早期适应性可以更有效，可以预测。
Due to stochastic fluctuations arising from finite population size, known as genetic drift, the ability of a population to explore a rugged fitness landscape depends on its size. In the weak mutation regime, while the mean steady-state fitness increases with population size, we find that the height of the first fitness peak encountered when starting from a random genotype displays various behaviors versus population size, even among small and simple rugged landscapes. We show that the accessibility of the different fitness peaks is key to determining whether this height overall increases or decreases with population size. Furthermore, there is often a finite population size that maximizes the height of the first fitness peak encountered when starting from a random genotype. This holds across various classes of model rugged landscapes with sparse peaks, and in some experimental and experimentally-inspired ones. Thus, early adaptation in rugged fitness landscapes can be more efficient and predictable for relatively small population sizes than in the large-size limit.
