论文标题
大脑中的思想在哪里？代谢受体和G蛋白门控离子通道的瞬时子网选择
Where is the mind within the brain? Transient selection of subnetworks by metabotropic receptors and G protein-gated ion channels
论文作者
论文摘要
大脑研究提出的最重要的问题也许是：大脑如何引起头脑。为了回答这个问题，我们主要依靠连接主义范式：人们认为大脑的全部知识和思维技能被认为存储在连接中；心理操作由网络计算执行。我在这里提出了一个替代范式：我们的知识和技能存储在代谢型受体（MRS）和G蛋白门控离子通道（GPGICS）中。在这里，假定MRS和GPGIC的功能可以执行心理操作。由于GPGIC具有关闭或开放树突树和轴突末端的能力，因此它们的状态在整个神经系统中暂时重新启动神经活动。首先，MRS检测配体，表明需要激活GPGIC。接下来，GPGIC瞬时选择大脑内的子网。选择这种新子网络的过程构成了心理操作 - 无论是以指向关注的形式，对祖母的感知还是做出决定。突触连接和网络计算仅扮演次要角色，支持MRS和GPGIC。根据这个新的范式，大脑内的思维是MRS和GPGIC的功能，其主要功能是不断选择允许神经活动通过的途径。有人认为，MRS和GPGICS解决了连接主义范式遭受的智力缩放问题。
Perhaps the most important question posed by brain research is: How the brain gives rise to the mind. To answer this question, we have primarily relied on the connectionist paradigm: The brain's entire knowledge and thinking skills are thought to be stored in the connections; and the mental operations are executed by network computations. I propose here an alternative paradigm: Our knowledge and skills are stored in metabotropic receptors (MRs) and the G protein-gated ion channels (GPGICs). Here, mental operations are assumed to be executed by the functions of MRs and GPGICs. As GPGICs have the capacity to close or open branches of dendritic trees and axon terminals, their states transiently re-route neural activity throughout the nervous system. First, MRs detect ligands that signal the need to activate GPGICs. Next, GPGICs transiently selects a subnetwork within the brain. The process of selecting this new subnetwork is what constitutes a mental operation -- be it in a form of directed attention, perception of a grandmother or making a decision. Synaptic connections and network computations play only a secondary role, supporting MRs and GPGICs. According to this new paradigm, the mind emerges within the brain as the function of MRs and GPGICs whose primary function is to continually select the pathways over which neural activity will be allowed to pass. It is argued that MRs and GPGICs solve the scaling problem of intelligence from which the connectionism paradigm suffers.
