论文标题

Etinex-QDPC:自动背景校正定量差异相位造影剂成像

Retinex-qDPC: automatic background rectified quantitative differential phase contrast imaging

论文作者

Zhang, Shuhe, Peng, Tao, Ke, Zeyu, Yang, Han, Berendschot, Tos T. J. M., Zhou, Jinhua

论文摘要

定量差异相对比重建(QDPC)的质量可以通过两个倾斜照明图像的背景的不匹配来严重退化,从而产生有问题的相位恢复结果。这些背景不匹配可能是由照明模式,不均匀的媒体分布或其他散落层引起的。在以前的报告中,背景是手动校准的,这是耗时且不稳定的,因为如果对光学系统进行了任何修改,则需要新的校准。当背景随着时间的推移而变化时,也不可能从散热器层中校准背景,或者进行高动态观察。为了解决背景的不匹配并增加了实验鲁棒性,我们提出了Etinex-QDPC,其中我们将图像边缘特征用作数据保真度项,从而获得L2-RETINEX-QDPC和L1-RETINEX-QDPC,以用于高背景 - 企业QDPC重建。 Bregman拆分方法用于求解L1-Retinex DPC。我们使用模拟数据和实验数据将两个Etinex-QDPC模型与包括总变化QDPC以及各向同性-QDPC在内的最新DPC重建算法进行了比较。结果表明,Itinex QDPC可以通过抑制不匹配背景的影响来显着提高相恢复质量。在内部,L1-RETINEX-QDPC优于L2-Retinex和其他最先进的DPC算法。通常,Etinex-QDPC提高了对背景照明的实验鲁棒性,而无需对光学系统进行任何修改,这将使所有QDPC应用都受益。

The quality of quantitative differential phase contrast reconstruction (qDPC) can be severely degenerated by the mismatch of the background of two oblique illuminated images, yielding problematic phase recovery results. These background mismatches may result from illumination patterns, inhomogeneous media distribution, or other defocusing layers. In previous reports, the background is manually calibrated which is time-consuming, and unstable, since new calibrations are needed if any modification to the optical system was made. It is also impossible to calibrate the background from the defocusing layers, or for high dynamic observation as the background changes over time. To tackle the mismatch of background and increases the experimental robustness, we propose the Retinex-qDPC in which we use the images edge features as data fidelity term yielding L2-Retinex-qDPC and L1-Retinex-qDPC for high background-robustness qDPC reconstruction. The split Bregman method is used to solve the L1-Retinex DPC. We compare both Retinex-qDPC models against state-of-the-art DPC reconstruction algorithms including total-variation regularized qDPC, and isotropic-qDPC using both simulated and experimental data. Results show that the Retinex qDPC can significantly improve the phase recovery quality by suppressing the impact of mismatch background. Within, the L1-Retinex-qDPC is better than L2-Retinex and other state-of-the-art DPC algorithms. In general, the Retinex-qDPC increases the experimental robustness against background illumination without any modification of the optical system, which will benefit all qDPC applications.

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