论文标题
整合癌模型的随机和参数分析
Stochastic and parameter analysis for an integrative cancer model
论文作者
论文摘要
在先前的工作中，我们提出了一个整合癌细胞分化和免疫疗法的模型，通过细胞毒性细胞疫苗分析针对癌症干细胞的特定疗法。由于每个生物系统都会暴露于随机波动，因此研究其随机性很重要。系统中人口统计学和乘法噪声的影响是在癌细胞中繁殖和死亡的参数上执行的。另一方面，我们通过添加乘法噪声来结合波动。在这两种情况下，我们分析了所涉及参数的不同值的动力学。发现这些参数的不同组合和噪声强度的最终量减少。
In a previous work, we presented a model that integrates cancer cell differentiation and immunotherapy, analysing a particular therapy against cancer stem cells by cytotoxic cell vaccines. As every biological system is exposed to random fluctuations, it is important to study its stochasticity. The influence of demographic and multiplicative noise in the system is carry out on the parameters of reproduction and death in cancer cells. On the other hand, we incorporated fluctuations by adding multiplicative noise. In both cases, we analysed the dynamics for different values of the parameters involved. The final amount of cancer cells decreases for different combinations of these parameters and noise intensity is found.
