论文标题
使用分子对接的SARS-COV-2重新利用药物
Drug Repurposing For SARS-COV-2 Using Molecular Docking
论文作者
论文摘要
药物重新利用是一种非常规的方法，用于研究现有药物和搁置药物的新治疗辅助工具。技术，蛋白质组学，转录组学等数据的最新进步以及可及可靠数据库资源的可访问性，有很多机会通过有效地重新利用药物来发现药物。迄今为止，最近导致6,245,750人死亡的SARS-COV-2大流行大大增加了生物信息学工具的特殊用法，以解释病毒感染的分子特征。 In this paper, we have employed various bioinformatics tools such as AutoDock-Vina, PyMol etc. We have found a leading drug candidate Cepharanthine that has shown better results and effectiveness than recently used antiviral drug candidates such as Favipiravir, IDX184, Remedesivir, Ribavirin and etc. This paper has analyzed Cepharanthine potential therapeutic importance as a drug of choice in managing 2019冠状病毒病病例。可以预计，拟议的研究在处理SARS-COV-2及其变体相关疾病方面对研究人员和医生有益。
Drug repurposing is an unconventional approach that is used to investigate new therapeutic aids of existing and shelved drugs. Recent advancement in technologies and the availability of the data of genomics, proteomics, transcriptomics, etc., and with the accessibility of large and reliable database resources, there are abundantly of opportunities to discover drugs by drug repurposing in an efficient manner. The recent pandemic of SARS-COV-2, that caused the death of 6,245,750 human beings to date, has tremendously increase the exceptional usage of bioinformatics tools in interpreting the molecular characterizations of viral infections. In this paper, we have employed various bioinformatics tools such as AutoDock-Vina, PyMol etc. We have found a leading drug candidate Cepharanthine that has shown better results and effectiveness than recently used antiviral drug candidates such as Favipiravir, IDX184, Remedesivir, Ribavirin and etc. This paper has analyzed Cepharanthine potential therapeutic importance as a drug of choice in managing COVID-19 cases. It is anticipated that proposed study would be beneficial for researchers and medical practitioners in handling SARS-CoV-2 and its variant related diseases.
