论文标题
由零和低场核磁共振研究的代谢反应
Metabolic Reactions Studied by Zero- and Low-Field Nuclear Magnetic Resonance
论文作者
论文摘要
最先进的磁共振成像使用超极化分子在体内跟踪新陈代谢，但是需要大的超导磁体，并且在存在导电材料的存在下，强磁场在很大程度上排除了磁易感性不中等的问题。以零和低场的运行来规避这些局限性，但由于灵敏度有限，直到现在一直不可能。我们表明，零场和低场核磁共振可用于探测两个重要的代谢反应：超极化富马酸盐向苹果酸和丙酮酸的转化为乳酸。这项工作为迄今未开发的生物医学成像应用类别铺平了道路。
State-of-the-art magnetic resonance imaging uses hyperpolarized molecules to track metabolism in vivo, but large superconducting magnets are required, and the strong magnetic fields largely preclude measurement in the presence of conductive materials and magnify problems of magnetic susceptibility inhomogeneity. Operating at zero and low field circumvents these limitations, but until now has not been possible due to limited sensitivity. We show that zero- and low-field nuclear magnetic resonance can be used for probing two important metabolic reactions: the conversion of hyperpolarized fumarate to malate and pyruvate to lactate. This work paves the way to a heretofore unexplored class of biomedical imaging applications.
