论文标题
催化引起的相分离和酶活性自动调节
Catalysis-Induced Phase Separation and Autoregulation of Enzymatic Activity
论文作者
论文摘要
我们提出了一个热力学一致的模型，该模型描述了多组分混合物的动力学，其中一种酶成分催化了其他成分之间的反应。我们发现，单独的催化活性可以诱导足够活跃的系统和大型酶的相分离，而组件之间没有任何平衡相互作用。在快速反应速率的限制下，可以使用映射到有效的自由能来计算二线线。我们还解释了这种催化诱导的相分离（CIP）如何自动调节酶促活性，这表明该现象的生物学相关性。
We present a thermodynamically consistent model describing the dynamics of a multi-component mixture where one enzyme component catalyzes a reaction between other components. We find that the catalytic activity alone can induce phase separation for sufficiently active systems and large enzymes, without any equilibrium interactions between components. In the limit of fast reaction rates, binodal lines can be calculated using a mapping to an effective free energy. We also explain how this catalysis-induced phase separation (CIPS) can act to autoregulate the enzymatic activity, which points at the biological relevance of this phenomenon.
