论文标题
信号传导振荡：分子机制和功能作用
Signaling oscillations: molecular mechanisms and functional roles
论文作者
论文摘要
越来越多的证据表明，振荡活性在细胞信号传导中广泛。在这里，我们回顾了一些最近的证据，重点介绍了潜在的动力学行为基础的分子机制，以及信号振荡可能在细胞功能中具有的潜在优势。所考虑的生物学过程包括组织维持，胚胎发育和伤口愈合。在数学建模的帮助下，我们表明了一个普遍的原理，即延迟的负面反馈，是这种现象的基础。
Mounting evidence shows that oscillatory activity is widespread in cell signaling. Here we review some of this recent evidence, focusing on both the molecular mechanisms that potentially underlie such dynamical behavior, and the potential advantages that signaling oscillations might have in cell function. The biological processes considered include tissue maintenance, embryonic development and wound healing. With the aid of mathematical modeling, we show that a common principle, namely delayed negative feedback, underpins this wide variety of phenomena.
