论文标题
使用电阻抗层摄影术对大脑实时高分辨率成像的可行性研究
A Feasibility Study on Real-Time High Resolution Imaging of the Brain Using Electrical Impedance Tomography
论文作者
论文摘要
目的:电阻抗断层扫描(EIT)的优势在于它通过使用非侵入性,辐射安全技术和缺乏已知危害来对内部进行成像的能力。在本文中,我们介绍了一种新颖的想法,即在深脑刺激(DBS)手术过程中使用EIT在微电极中使用,以获得微电极周围脑组织的电导率的图像。 DBS是一种手术治疗,涉及植入大脑中的医疗探针。对于这种应用,EIT重建方法必须提供针对噪声的高质量和鲁棒性。方法:在本文中引入了用于开放域EIT的后处理方法,该方法结合了线性和非线性方法,以便将两者的优势和有限的缺点使用。重建方法是一种两步方法,第一个方法通过线性算法解决了反问题,第二个方法将非线性方面带回图像中。结果:所提出的方法在模拟和幻影数据上进行了测试,并与三种广泛使用的EIT成像方法进行了比较。结果图像和错误为提出的解决方案带来了强大的优势。结论:幻影数据的高质量重建验证了新型重建方法的效率。意义:这项可行性研究提出了一种有效的开放域EIT方法,并为临床试验打开了道路。
Objective: The strengths of Electrical Impedance Tomography (EIT) are its capability of imaging the internal body by using a noninvasive, radiation safe technique, and the absence of known hazards. In this paper we introduce a novel idea of using EIT in microelectrodes during Deep Brain Stimulation (DBS) surgery in order to obtain an image of the electrical conductivities of the brain tissues surrounding the microelectrodes. DBS is a surgical treatment involving the implantation of a medical probe inside the brain. For such application, the EIT reconstruction method has to offer both high quality and robustness against noise. Methods: A post-processing method for open-domain EIT is introduced in this paper, which combines linear and nonlinear methods in order to use the advantages of both with limited drawbacks. The reconstruction method is a two-steps method, the first solves the inverse problem with a linear algorithm and the second brings the nonlinear aspects back into the image. Results: The proposed method is tested on both simulation and phantom data, and compared to three widely used method for EIT imaging. Resulting images and errors gives a strong advantage to the proposed solution. Conclusion: High quality reconstruction from phantom data validates the efficiency of the novel reconstruction method. Significance: This feasibility study presents an efficient method for open domain EIT and opens the way to clinical trials.