论文标题

通过自我监督学习和共同培训从病理图像中进行点注释的细胞核分割

Nuclei Segmentation with Point Annotations from Pathology Images via Self-Supervised Learning and Co-Training

论文作者

Lin, Yi, Qu, Zhiyong, Chen, Hao, Gao, Zhongke, Li, Yuexiang, Xia, Lili, Ma, Kai, Zheng, Yefeng, Cheng, Kwang-Ting

论文摘要

细胞核分割是数字病理中整个幻灯片图像分析的关键任务。通常,完全监督学习的细分性能在很大程度上取决于注释数据的数量和质量。但是,专业病理学家提供准确的像素级地面真相是耗时且昂贵的,而获取诸如点注释之类的粗标签也容易得多。在本文中,我们提出了一种弱监督的学习方法来进行核分割,该方法仅需要训练点注释。首先,粗像素级标签是从基于Voronoi图和K-均值聚类方法的点注释中得出的,以避免过度拟合。其次,具有指数移动平均方法的共同训练策略旨在完善对粗标签的不完整监督。第三,针对病理图像的核分割量身定制了一种自我监督的视觉表示学习方法,该方法将苏木精的图像转化为H&E染色图像,以更好地了解细胞核与细胞质之间的关系。我们使用两个公共数据集全面评估了提出的方法。视觉和定量结果都证明了我们方法对最先进方法的优越性,并且与完全监督的方法相比,其竞争性能。代码:https://github.com/hust-linyi/sc-net

Nuclei segmentation is a crucial task for whole slide image analysis in digital pathology. Generally, the segmentation performance of fully-supervised learning heavily depends on the amount and quality of the annotated data. However, it is time-consuming and expensive for professional pathologists to provide accurate pixel-level ground truth, while it is much easier to get coarse labels such as point annotations. In this paper, we propose a weakly-supervised learning method for nuclei segmentation that only requires point annotations for training. First, coarse pixel-level labels are derived from the point annotations based on the Voronoi diagram and the k-means clustering method to avoid overfitting. Second, a co-training strategy with an exponential moving average method is designed to refine the incomplete supervision of the coarse labels. Third, a self-supervised visual representation learning method is tailored for nuclei segmentation of pathology images that transforms the hematoxylin component images into the H&E stained images to gain better understanding of the relationship between the nuclei and cytoplasm. We comprehensively evaluate the proposed method using two public datasets. Both visual and quantitative results demonstrate the superiority of our method to the state-of-the-art methods, and its competitive performance compared to the fully-supervised methods. Code: https://github.com/hust-linyi/SC-Net

扫码加入交流群

加入微信交流群

微信交流群二维码

扫码加入学术交流群,获取更多资源