论文标题
与染色质空间组织有关的具有偶极活性力的聚合物链
A Polymer Chain with Dipolar Active Forces in Connection to Spatial Organization of Chromatin
论文作者
论文摘要
活细胞是一个活跃的环境，在该环境中，染色质的组织和动力学受不同形式的活性影响。光学实验报告表明，基因座表现出亚延伸动力学和染色质纤维在微米尺度区域之间是连贯的。使用带有偶极活性力的珠子弹簧聚合物链，我们研究了基因座的副延伸运动如何产生染色质的大规模连贯运动。我们表明，与没有偶性力相比，在存在大量（收缩）活性的存在下，基因座的动力学增长更快（较慢），空间相关长度增加（减小）。因此，偶极活性力都会改变链的弹性。有趣的是，在我们的模型中，这种偶极活动链的动力学和组织与被重新归一化的弹性与被动链有很大不同。
A living cell is an active environment where the organization and dynamics of chromatin are affected by different forms of activity. Optical experiments report that loci show subdiffusive dynamics and the chromatin fiber is seen to be coherent over micrometer-scale regions. Using a bead-spring polymer chain with dipolar active forces, we study how the subdiffusive motion of the loci generate large-scale coherent motion of the chromatin. We show that in the presence of extensile (contractile) activity, the dynamics of loci grows faster (slower) and the spatial correlation length increases (decreases) compared to the case with no dipolar forces. Hence, both the dipolar active forces modify the elasticity of the chain. Interestingly in our model, the dynamics and organization of such dipolar active chains largely differ from the passive chain with renormalized elasticity.
