论文标题

将域的生长纳入反应扩散系统的混合方法

Incorporating domain growth into hybrid methods for reaction-diffusion systems

论文作者

Smith, Cameron A., Yates, Christian A.

论文摘要

反应 - 扩散机制是一种可靠的范式,可用于在多个空间尺度上代表许多生物学和物理现象。应用包括细胞内动力学,细胞的迁移以及半干旱景观中植被形成的模式。此外,域的生长是胚胎生长和伤口愈合的重要过程。有许多能够在生长域上模拟此类系统的数值建模框架,但是每个系统都可以很好地适用于不同的空间尺度和粒子。最近,为了弥合这些不同建模范式之间的差距,以代表多尺度现象,因此已经产生了静态结构域的空间扩展的混合方法。但是,考虑到领域的增长,这种方法尚未开发出来。在本文中,我们开发了三种有关生长域的混合方法,扩展了三种突出的静态结构域混合方法。我们还提供详细的算法,以允许其他人雇用它们。我们证明了这些方法能够准确地对三个代表性反应扩散系统进行准确地建模,并且没有偏置。

Reaction--diffusion mechanism are a robust paradigm that can be used to represent many biological and physical phenomena over multiple spatial scales. Applications include intracellular dynamics, the migration of cells and the patterns formed by vegetation in semi-arid landscapes. Moreover, domain growth is an important process for embryonic growth and wound healing. There are many numerical modelling frameworks capable of simulating such systems on growing domains, however each of these may be well suited to different spatial scales and particle numbers. Recently, spatially extended hybrid methods on static domains have been produced in order to bridge the gap between these different modelling paradigms in order to represent multiscale phenomena. However, such methods have not been developed with domain growth in mind. In this paper, we develop three hybrid methods on growing domains, extending three of the prominent static domain hybrid methods. We also provide detailed algorithms to allow others to employ them. We demonstrate that the methods are able to accurately model three representative reaction-diffusion systems accurately and without bias.

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