论文标题
对DNA tata-box变形的构象影响
Conformational impact on deformation of DNA TATA-box
论文作者
论文摘要
列出了DNA双螺旋tata-box的特殊序列的可变形性的理论研究。该论文详细阐述了DNA TATA-box双螺旋异常变形的机制，该机制无法使用聚合物分子（WLC）的标准机械模型来解释，并且需要更详细的建模。 DNA TATA-box变形的分析表明，由于其结构多态性的特性，Molucule可以经历显着的变形，也就是说，双螺旋片段的可能性比一种构象更多。除了弹性组件（弯曲，扭曲）外，提出的模型还包括以下变形特征：糖环形状的构象重排的可能性，特定核苷酸序列和各向异性的影响，组件之间的耦合。提出的模型允许根据双螺旋内部结构的物理特殊拟合来描述异常变形。
The theoretical study of deformability of special sequence of DNA double helix TATA-box is presentated. The paper elaborates on the mechanisms of abnormal deformation of DNA TATA-box double helix that cannot be explained using the standard mechanical model of polymer molecules (WLC) and needs more detailed modeling. Analyzing of DNA TATA-box deformation it is shown the molucule can undergo significant deformations due to its property of the structural polymorphism, that is, possibility of the double helix fragment to exist in more then one conformations. In addition to elastic components (bending, twisting), the presented model includes the following deformation features: possibility of conformation rearrangement of the shapes of the sugar rings, effects of a specific nucleotide sequence and anisotropy, the coupling between components. Presented model allows describe abnormal deformation based on physical special fitures of double helix inner structure.
