论文标题
对登革热生物控制的Mendelian和母体遗传的建模和控制
Modelling and control of Mendelian and maternal inheritance for biological control of dengue vectors
论文作者
论文摘要
蚊子是世界许多地区具有流行潜力的病毒疾病的载体，在没有疫苗或疗法的情况下，它们的控制是主要的选择。通过杀虫剂的化学控制一直是传统策略之一，但会诱导杀虫剂耐药性，这可能会影响其他昆虫并造成生态损害。通过释放由母体遗传的细菌抑制其载体能力的蚊子，生物控制已被提议作为替代品。两种技术的影响都可能在实践中混合在一起：先前的杀虫剂喷涂可能会使野生种群减弱，从而促进细菌随后的侵袭；但是，由于曾经存在的不期望的杀虫剂的表明，在野生种群变得抗性的环境中释放易感蚊子也可能会阻碍后者。为了应对这种情况，我们在这里提出了一个统一模型，以说明两种控制技术的交叉效应，并根据后者的设计发布策略，能够感染野生人群。后者是反馈定律，研究了其稳定属性。
Mosquitoes are vectors of viral diseases with epidemic potential in many regions of the world, and in absence of vaccines or therapies, their control is the main alternative. Chemical control through insecticides has been one of the conventional strategies, but induces insecticide resistance, which may affect other insects and cause ecological damage. Biological control, through the release of mosquitoes infected by the maternally inherited bacterium Wolbachia, which inhibits their vector competence, has been proposed as an alternative. The effects of both techniques may be intermingled in practice: prior insecticide spraying may debilitate wild population, so facilitating subsequent invasion by the bacterium; but the latter may also be hindered by the release of susceptible mosquitoes in an environment where the wild population became resistant, as a result of preexisting undesired exposition to insecticide. To tackle such situations, we propose here a unifying model allowing to account for the cross effects of both control techniques, and based on the latter, design release strategies able to infect a wild population. The latter are feedback laws, whose stabilizing properties are studied.
