论文标题
反卷积的光学分辨率光声显微镜，用于大脑的高分辨率成像
Deconvolution optical-resolution photoacoustic microscope for high -resolution imaging of brain
论文作者
论文摘要
我们提出了一个反卷积的光学分辨率光声显微镜，用于大脑的高分辨率成像。测量光声显微镜的焦点以获得系统的横向PSF（点扩散函数）。使测量的PSF作为初始系统PSF，以执行Lucy-Richardson（LR）反卷积。通过该方法获得的大脑脉管系统的图像分辨率更高。反卷积之前和之后血管宽度的一半（FWHM）的全宽度分别为7微米和3.6微米，并且图像定义的全宽度分别增加了约1.9倍。实验表明，这种方法可以进一步提高脑脉管系统的光声图像的清晰度，这为进一步的脑成像研究奠定了基础。
We proposed a deconvolution optical-resolution photoacoustic microscope for high -resolution imaging of brain. The focal spot of the photoacoustic microscopy is measured to obtain the lateral PSF (point spread function) of the system. Making the measured PSF as the initial system PSF to perform Lucy- Richardson (LR) deconvolution. The image resolution of cerebral vasculature obtained by this method is higher. The full width at half maximum (FWHM) of the width of blood vessel before and after deconvolution are 7 micrometers and 3.6 micrometers, respectively, and the image definition is increased by about 1.9 times. Experiments show that this method can further improve the clarity of photoacoustic images of cerebral vasculature, which lays the foundation for further research on brain imaging.
