论文标题
DNA结合蛋白扩散动力学的微型审查：实验和模型
A mini-review of the diffusion dynamics of DNA-binding proteins: Experiments and models
论文作者
论文摘要
在各种生物学过程的过程中，特定的DNA结合蛋白必须有效地在DNA上找到特定的靶序列/蛋白质或受损位点。 DNA结合蛋白基于扩散执行此任务。然而，近几十年来的研究发现，DNA结合蛋白的扩散动力学通常是复杂的，而且是蛋白质特异性的。在这篇综述中，我们收集了量化DNA结合蛋白的扩散动力学的实验和理论研究，并从扩散过程的角度进行了审查。
In the course of various biological processes, specific DNA-binding proteins must find a particular target sequence/protein or a damaged site on the DNA efficiently. DNA-binding proteins perform this task based on diffusion. Yet, investigations over recent decades have found that the diffusion dynamics of DNA-binding proteins are generally complicated and, further, protein-specific. In this review, we collect the experimental and theoretical studies that quantify the diffusion dynamics of DNA-binding proteins and review them from the viewpoint of diffusion processes.
