论文标题
癌细胞和正常细胞基因调节网络中三角形不平衡的稳定性
Stability of Imbalanced Triangles in Gene Regulatory Networks of Cancerous and Normal Cells
论文作者
论文摘要
基因通过不同的调节作用相互通信，这会导致细胞中复杂结构的出现，并且预期这种结构对于正常和癌细胞而言有所不同。为了研究乳腺癌的差异，我们研究了RNA测序数据推断出的细胞基因调节网络（GRN）。 GRN是与电感或抑制性相互作用相对应的符号加权网络。在这里，我们专注于GRN中的特定图案，即三角形，如果负相互作用的数量很奇怪，则会不平衡。通过研究GRN中三角形不平衡的稳定性，我们表明癌细胞网络与正常情况相比，三角形的不平衡不平衡。此外，在正常细胞中，从网络的主要部分分离出不平衡的三角形，而这种基序是网络中癌细胞中网络巨型成分的一部分。我们的结果表明，由于基因的集体行为，癌细胞中的复杂结构与正常细胞不同。
Genes communicate with each other through different regulatory effects, which lead to the emergence of complex structures in cells, and such structures are expected to be different for normal and cancerous cells. To study breast cancer differences, we have investigated the Gene Regulatory Network (GRN) of cells as inferred from RNA-sequencing data. The GRN is a signed weighted network corresponding to the inductive or inhibitory interactions. Here we focus on a particular of motifs in the GRN, the triangles, which are imbalanced if the number of negative interactions are odd. By studying the stability of imbalanced triangles in the GRN, we show that the network of cancerous cells has fewer imbalanced triangles compared to normal. Moreover, in the normal cells, imbalanced triangles are isolated from the main part of the network, while such motifs are part of the network's giant component in cancerous cells. Our result demonstrates that due to genes' collective behavior the complex structures are different in cancerous cells from those in normal ones.
