论文标题
离子通道记录的异构理想化 - 开放通道噪声
Heterogeneous Idealization of Ion Channel Recordings -- Open Channel Noise
论文作者
论文摘要
我们提出了一种用于理想化离子通道记录的新的无模型分割方法。该方法旨在处理测量误差的异质性。这特别适用于开放通道噪声，通常，对于无模型方法，这通常很难应对。我们的方法能够处理低通过滤数据，这提供了进一步的计算挑战。为此，我们提出了一种多分辨率测试方法，并结合局部反卷积来解决低通滤波器。仿真和统计理论证实，提出的理想化在存在异质噪声的情况下非常准确地恢复了基础信号，即使事件短于滤波器长度。将该方法与计算机实验和实际数据中的现有方法进行比较。我们发现，它是唯一允许在两个不同的时间尺度上识别Porb Porine的开口的一种。实现可作为R软件包使用。
We propose a new model-free segmentation method for idealizing ion channel recordings. This method is designed to deal with heterogeneity of measurement errors. This in particular applies to open channel noise which, in general, is particularly difficult to cope with for model-free approaches. Our methodology is able to deal with lowpass filtered data which provides a further computational challenge. To this end we propose a multiresolution testing approach, combined with local deconvolution to resolve the lowpass filter. Simulations and statistical theory confirm that the proposed idealization recovers the underlying signal very accurately at presence of heterogeneous noise, even when events are shorter than the filter length. The method is compared to existing approaches in computer experiments and on real data. We find that it is the only one which allows to identify openings of the PorB porine at two different temporal scales. An implementation is available as an R package.
