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Einstein's General Relativity (GR) is possibly one of the greatest intellectual achievements ever conceived by the human mind. In fact, over the last century, GR has proven to be an extremely successful theory, with a well established experimental footing. However, the discovery of the late-time cosmic acceleration, which represents a new imbalance in the governing gravitational field equations, has forced theorists and experimentalists to question whether GR is the correct relativistic theory of gravitation, and has spurred much research in modified gravity, where extensions of the Hilbert-Einstein action describe the gravitational field. In this review, we perform a detailed theoretical and phenomenological analysis of two largely explored extensions of $f(R)$ gravity, namely: (i) the hybrid metric-Palatini theory; (ii) and modified gravity with curvature-matter couplings. Relative to the former, it has been established that both metric and Palatini versions of $f(R)$ gravity possess interesting features but also manifest severe drawbacks. A hybrid combination, containing elements from both of these formalisms, turns out to be very successful in accounting for the observed phenomenology and avoids some drawbacks of the original approaches. Relative to the curvature-matter coupling theories, these offer interesting extensions of $f(R)$ gravity, where the explicit nonminimal couplings between an arbitrary function of the scalar curvature $R$ and the Lagrangian density of matter, induces a non-vanishing covariant derivative of the energy-momentum tensor. We extensively explore both theories in a plethora of applications, namely, the weak-field limit, galactic and extragalactic dynamics, cosmology, stellar-type compact objects, irreversible matter creation processes and the quantum cosmology of a specific curvature-matter coupling theory.