论文标题
重建方案的兴奋性和抑制性动力学与猝灭障碍：应用于斑马鱼成像
Reconstruction scheme for excitatory and inhibitory dynamics with quenched disorder: application to zebrafish imaging
论文作者
论文摘要
开发和测试了一个反过程，以从全球活动的全球信号中恢复功能和结构信息。该方法假设具有兴奋性和抑制性神经元的泄漏和火模型，并通过有向网络耦合。神经元具有异质电流值，该值设定了其相关的动力学状态。通过利用异源均值场近似，该方法试图从全球活动模式中重建兴奋性和抑制神经元以及分配的电流的分布。首先针对合成数据验证了所提出的反方案。然后，用两光子光显微镜记录的斑马鱼幼虫的延时采集用作重建算法的输入。发现了兴奋性神经元的室内连通性的功率定律分布。还通过从注释的地图集中追踪的子区域中的整个大脑进行分割来计算局部程度分布。
An inverse procedure is developed and tested to recover functional and structural information from global signals of brains activity. The method assumes a leaky-integrate and fire model with excitatory and inhibitory neurons, coupled via a directed network. Neurons are endowed with a heterogenous current value, which sets their associated dynamical regime. By making use of a heterogenous mean-field approximation, the method seeks to reconstructing from global activity patterns the distribution of in-coming degrees, for both excitatory and inhibitory neurons, as well as the distribution of the assigned currents. The proposed inverse scheme is first validated against synthetic data. Then, time-lapse acquisitions of a zebrafish larva recorded with a two-photon light sheet microscope are used as an input to the reconstruction algorithm. A power law distribution of the in-coming connectivity of the excitatory neurons is found. Local degree distributions are also computed by segmenting the whole brain in sub-regions traced from annotated atlas.
