论文标题
从添加剂量表上二进制风险因素之间的两次相互作用到多路相互作用
Moving from two- to multi-way interactions among binary risk factors on the additive scale
论文作者
论文摘要
许多研究的重点是研究二进制结果的两个二分法风险因素的加性相互作用的偏差。但是，文献中关于> 2个风险因素的添加量表的相互作用存在差距。在本文中，我们提出了一种检查在更多二进制暴露的三个相互作用之间偏离添加剂相互作用的方法。由于相互作用（RERI）引起的相对多余风险用作添加剂相互作用的量度。首先，我们集中于三个风险因素 - 我们建议将总重新列入总重新分解为：归功于所有3个危险因素的共同存在和任何两个风险因素的重新归因，鉴于第三个危险因素不存在。然后，我们将这种方法扩展到> 3个二元风险因素。为了进行说明，我们使用了来自希腊史诗队列的数据的样本，并研究了与地中海饮食，体重指数（BMI）和吸烟的总体死亡率的关联。我们的公式可以更好地解释与两个以上风险因素拥有的添加性偏差的任何证据，并通过将任何过多的相对风险归因于这些因素的特定组合，从而提供了简单的方式来从公共卫生的角度传达此类结果。
Many studies have focused on investigating deviations from additive interaction of two dichotomous risk factors on a binary outcome. There is, however, a gap in the literature with respect to interactions on the additive scale of >2 risk factors. In this paper, we present an approach for examining deviations from additive interaction among three on more binary exposures. The relative excess risk due to interaction (RERI) is used as measure of additive interaction. First, we concentrate on three risk factors - we propose to decompose the total RERI to: the RERI owned to the joint presence of all 3 risk factors and the RERI of any two risk factors, given that the third is absent. We then extend this approach, to >3 binary risk factors. For illustration, we use a sample from data from the Greek EPIC cohort and we investigate the association with overall mortality of Mediterranean diet, body mass index (BMI), and, smoking. Our formulae enable better interpretability of any evidence for deviations from additivity owned to more than two risk factors and provide simple ways of communicating such results from a public health perspective by attributing any excess relative risk to specific combinations of these factors.
