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Globular cluster progenitors may have been detected by \textit{HST}, and are predicted to be observable with \textit{JWST} and ground-based extremely-large telescopes with adaptive optics. This has the potential to elucidate the issue of globular cluster formation and the origins of significantly helium-enriched subpopulations, a problem in Galactic astronomy with no satisfactory theoretical solution. Given this context, we use model stellar tracks and isochrones to investigate the predicted observational properties of helium-enriched stellar populations in globular cluster progenitors. We find that, relative to helium-normal populations, helium-enriched ($ΔY=+0.12$) stellar populations similar to those inferred in the most massive globular clusters, are expected, modulo some rapid fluctuations in the first $\sim$30 Myr, to be brighter and redder in the rest frame. At fixed age, stellar mass, and metallicity, a helium-enriched population is predicted to converge to being $\sim$0.40 mag brighter at $λ\approx 2.0\, μm$, and to be 0.30 mag redder in the \textit{JWST}-NIRCam colour $(F070W-F200W)$, and to actually be fainter for $λ\lesssim 0.50 \, μm$. Separately, we find that the time-integrated shift in ionizing radiation is a negligible $\sim 5\%$, though we show that the Lyman-$α$ escape fraction could end up higher for helium-enriched stars.