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The Potjans-Diesmann cortical microcircuit model is a widely used model originallyimplemented in NEST. Here, we re-implemented the model using NetPyNE, a high-level Python interface to the NEURON simulator, and reproduced the findings of theoriginal publication. We also implemented a method for rescaling the network sizewhich preserves first and second order statistics, building on existing work on networktheory. The new implementation enables using more detailed neuron models with mul-ticompartment morphologies and multiple biophysically realistic channels. This opensthe model to new research, including the study of dendritic processing, the influenceof individual channel parameters, and generally multiscale interactions in the network.The rescaling method provides flexibility to increase or decrease the network size ifrequired when running these more realistic simulations. Finally, NetPyNE facilitatesmodifying or extending the model using its declarative language; optimizing modelparameters; running efficient large-scale parallelized simulations; and analyzing themodel through built-in methods, including local field potential calculation and informa-tion flow measures.