学术文献库

The structure and dynamics of tissue cultures depend strongly on the physical and chemical properties of the underlying substrate. Inspired by previous advances in the context of inorganic materials, the use of patterned culture surfaces has been proposed as an effective way to induce space-dependent properties in cell tissues. However, cells move and diffuse and the transduction of external stimuli to biological signals is not instantaneous. Here, we show that the fidelity of patterns depends on the relation between the diffusion ($τ_D$) and adaptation ($τ$) times. Numerical results for the self-propelled Voronoi model reveal that the fidelity decreases with $τ/τ_D$, a result that is reproduced by a continuum reaction-diffusion model. We derive a minimum length scale for the patterns that depends on $τ/τ_D$ and can be much larger than the cell size.