论文标题
取代的嘧啶的自由基清除和细胞毒性活性
Free Radical Scavenging and Cytotoxic Activities of Substituted Pyrimidines
论文作者
论文摘要
合成了一个取代的嘧啶库，并评估了3T3细胞中的自由基清除和体外细胞毒性活性。与标准的IC50值为128.83 2。1μm相比，所有化合物均显示出良好的自由基清除活性，IC50值在42.9 + 0.31至438.33.3μm的范围内，均为42.9 + 0.31至438.33.3μm。还建立了结构活动关系。选定的类似物1、2、3、5、6、7、9、9、10、13、13、13、21、21、21、21、24、25、26和28测试了MTT分析的小鼠成纤维细胞3T3细胞系的细胞毒性，并且大多数类似物都显示出细胞毒性。这项研究已经确定了许多具有自由基清除活性的细胞毒性新型取代的嘧啶，可以用作抑制性化合物，用于那些由活性氧介导的癌细胞。
A library of substituted pyrimidines was synthesized and evaluated for free radical scavenging, and in vitro cytotoxic activity in 3T3 cells. All compounds showed good free radical scavenging activity with IC50 values in the range of 42.9 + 0.31 to 438.3 3.3 μM as compared to the standard butylated hydroxytoluene having IC50 value of 128.83 2. 1 μM. The structure activity-relationship was also established. Selected analogues 1, 2, 3, 5, 6, 7, 8, 9, 10, 12, 13, 15, 19, 20, 21, 24, 25, 26 and 28 were tested for cytotoxicity in mouse fibroblast 3T3 cell line using MTT assay, and most of the analogues showed cytotoxicity. This study has identified a number of cytotoxic novel substituted pyrimidines having free radical scavenging activities that can be used as inhibitory compounds for those cancer cells whose growth is mediated by reactive oxygen species.
