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Due to major breakthroughs in software and engineering technologies, embedded systems are increasingly being utilized in areas ranging from aerospace and next-generation transportation systems, to smart grid and smart cities, to health care systems, and broadly speaking to what is known as Cyber-Physical Systems (CPS). A CPS is primarily composed of several electronic, communication and controller modules and some actuators and sensors. The mix of heterogeneous underlying smart technologies poses a number of technical challenges to the design and more severely to the verification of such complex infrastructure. In fact, a CPS shall adhere to strict safety, reliability, performance and security requirements, where one needs to capture both physical and random aspects of the various CPS modules and then analyze their interrelationship across interlinked continuous and discrete dynamics. Often times however, system bugs remain uncaught during the analysis and in turn cause unwanted scenarios that may have serious consequences in safety-critical applications. In this paper, we introduce some of the challenges surrounding the design and verification of contemporary CPS with the advent of smart technologies. In particular, we survey recent developments in the use of theorem proving, a formal method, for the modeling, analysis and verification of CPS, and overview some real world CPS case studies from the automotive, avionics and healthtech domains from system level to physical components.