论文标题
受控的邻居交换驱动上皮组织中的玻璃性行为，间歇性和细胞流
Controlled neighbor exchanges drive glassy behavior, intermittency and cell streaming in epithelial tissues
论文作者
论文摘要
细胞邻居交换是生物学中组织重排的组成部分，包括开发和修复。这些过程通常通过拓扑T1转变发生，类似于在泡沫，谷物和胶体中观察到的过程。但是，与非生存材料相比，生物组织中的T1转变是限制的，并且由于在细胞细胞连接处重塑复合物所需的有限时间，因此无法立即发生。在这里，我们研究了这种限制过程如何通过在基于理论顶点的模型中引入这种重要的生物学约束来影响组织中细胞在组织中的力学和集体行为。我们报告没有此时间限制，组织经历了运动驱动的玻璃转变，其特征是细胞细胞重排的间歇性急剧增加。值得注意的是，由于T1转变在时间上受到限制，因此这种玻璃转变消失了。作为有限重排有限的独特结果，我们还发现组织会形成快速和慢细胞的空间相关流，其中快速细胞将其组织成具有领导者 - 追随者相互作用的流样模式，并保持最佳的稳定稳定的细胞电池接触。将这项工作的预测与果蝇开发中现有的体内实验进行了比较。
Cell neighbor exchanges are integral to tissue rearrangements in biology, including development and repair. Often these processes occur via topological T1 transitions analogous to those observed in foams, grains and colloids. However, in contrast to in non-living materials the T1 transitions in biological tissues are rate-limited and cannot occur instantaneously due to the finite time required to remodel complex structures at cell-cell junctions. Here we study how this rate-limiting process affects the mechanics and collective behavior of cells in a tissue by introducing this important biological constraint in a theoretical vertex-based model as an intrinsic single-cell property. We report in the absence of this time constraint, the tissue undergoes a motility-driven glass transition characterized by a sharp increase in the intermittency of cell-cell rearrangements. Remarkably, this glass transition disappears as T1 transitions are temporally limited. As a unique consequence of limited rearrangements, we also find that the tissue develops spatially correlated streams of fast and slow cells, in which the fast cells organize into stream-like patterns with leader-follower interactions, and maintain optimally stable cell-cell contacts. The predictions of this work is compared with existing in-vivo experiments in Drosophila pupal development.
